I do cancer research, specifically focus on how physiological signals and signaling pathways that affect cellular proliferation are directly or indirectly associated with the molecular machinery that controls cell cycle regulation. We want to understand the molecular mechanisms that regulate cell cycle progression and their possible functional alternations during carcinogenesis. We design and apply different integrative strategies that use diverse computational tools to elucidate new molecular components that regulate cell cycle progression. Similarly, we search for new associative dynamics among the fundamental cell cycle elements that may have a direct effect on the initiation or progress of the carcinogenic process.
We apply forward and reverse genetics strategies in Arabidopsis thaliana for the identification of novel genes and proteins that could be directly associated with cell cycle regulation. Concomitantly, we perform comparative genomics in order establish direct phylogenetic associations between the found genes in Arabidopsis and its human counterparts whose probable function in cell cycle regulation also in humans could be associated with cancer origin or progression when altered.
Our lab is equipped to follow an experimental pipeline using Arabidopsis thaliana as well, it is designed to use cancer cell lines, cell biology tools and RNAi technology for identifying and characterizing new regulatory genes associated with cell cycle and cancer progression.
Currently Funded Research
Detection and characterization of potential oncogenes or tumor suppressors using cell biology and RNAi tools. Implementation of a detection and characterization strategy of new cellular cycle regulatory genes in Arabidopsis thaliana and potential oncogenes or tumoral suppressors in humans (grant: Javeriana), and Construction and topological characterization of the protein interaction network associated to the distinctive marks in a carcinogenic process (grant: Javeriana).